Shared Research Facilities and Equipment

Many facilities across North Carolina support life science research.

The listing covers core laboratory facilities at university and nonprofit research institutions that are open to researchers or collaborators outside of their home institutions.

Representatives of the core facilities listed below have voluntarily submitted their information. Not all institutions list available core lab facilities, but many are in the process of organizing and compiling these resources. As this information becomes available, we'll add those links.

NCBiotech has funded equipment in many core facilities in the state.

The Center's ongoing role is to provide this information portal. If you would like to submit a new listing or update an existing listing please reach out to Susan Lankford.

 

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Region
Category
Facility Institution
Piedmont Triad
Winston-Salem
The Proteomics and Metabolomics Shared Resource provides broad mass spectrometry services to academic and industry investigators. The PMSR mission is to provide access to advanced mass spectrometry techniques for quantitation and identification of proteins, metabolites and other molecules of interest in biological and clinical samples. In addition to the fee-for-service, the Shared Resource offers options to accommodate various needs such as training and project-based collaborations. All services are scheduled and managed through iLab https://wfbmc.ilabsolutions.com/account/login).
More information/services:

proteomics (discovery and targeted analysis of proteins and posttranslational modifications including phosphorylation, acetylation, oxidation, etc)), metabolomics, lipidomics, pharmacokinetics

  • Other -omics & Analytical
  • Other -omics & Analytical
Cristina M. Furdui
cfurdui@wakehealth.edu
(336) 716-2697
Greater Charlotte
Charlotte
We are a histology oriented core lab that has the ability to perform a range of histological services. Mallory Korman, HTL (ASCP) has recently joined the team as the supervisor and primary contact for scientific help. Prior to this position, Mallory had managed the Research Histology Core laboratory at Stony Brook Medical Center in New York for five years and had maintained excellent standards quality, effectiveness and efficiency. These standards are our top priority here at Carolinas HealthCare System and we will be more than happy to help you obtain your histological goals. We offer scientific help to help clients prepare for their study in order to yield the most optimal histological results. We work with a large range of species which also includes human sample studies. We feel it’s important to first help the client to understand the best possible ways to prepare their samples depending on what assays they would like to have completed. This helps to ensure that the obtained results are as optimal as possible.
More information/services:

histological processing, paraffin embedding, sectioning tissue via microtome as well as cryostat, H&E staining, immunohistochemistry, immunofluorescence, bone decalcification, tissue microarray construction

  • Pathology/Histology
Mallory Korman
Mallory.Korman@CarolinasHealthCare.org
704-446-4632
Triangle
Durham
SMIF provides researchers with access to advanced characterization and clean room fabrication capabilities. SMIF is available to all Duke University researchers and to external users from other universities, government labs, and industry. Small Angle X-Ray Scattering, Micro-CT X-Ray imaging
More information/services:

Electron Microscopy(SEM,TEM),Atomic Force Microscopy,Optical Spectroscopy(Raman,TIR,UV-Vis),XPS, X-ray Diffraction,E-Beam & Optical Lithography,Evaporation,Sputter & PECVD Deposition, RIE & Chemical Etching, Furnace Processing

  • Crystallography, X-ray Diffraction, NMR, & EPR
  • Imaging & Microdissection
  • Nanotechnology
Mark D. Walters, Ph.D.
mark.walters@duke.edu
(919) 660-5486
University of North Carolina at Greensboro
Piedmont Triad
Greensboro
The TMS Laboratory provides mass spectrometry analysis and training to the UNC-Greensboro campus community and the surrounding Piedmont Triad. Our instrumentation can be tailored to small molecule, metabolomics, and/or protein/peptide analyses. Ionization Sources: ESI, APPI, APCI, MALDI, DESI Separation Instrumentation: Waters Aquity UPLC, Agilent 1100 HPLC Open to scientific researchers in the Piedmont Triad on a fee for service basis who are in need of mass spectrometry analysis. (Please see website http:triadmslab.uncg.edu)
More information/services:

MS instrumentation: Thermo Q Exactive Plus, Thermo LTQ Orbitrap XL, Thermo TSQ Quantum Access (triple quad), Waters Synapt G2 HDMS qTOF, Shimadzu GC-MS

  • Other -omics & Analytical
Daniel A. Todd, Ph.D.
Datodd3@uncg.edu
(336) 334-4768
Triangle
Chapel Hill
The CGIBD’s Advanced Analytics (AA) Core provides high-quality, quantitative solutions for studying proteins and nucleic acids at the bulk or single-cell level. The Core offers a wide variety of services, including: single cell genomics (10x Genomics and Fluidigm C1), single cell protein detection (Protein Simple Milo), high-throughput PCR/qPCR (Fluidigm BioMark HD), immunoassays (ELISA/EIA/multiplex), cell sorting (FACS), and Illumina sequencing (NextSeq 500).
More information/services:

10x Genomics, Fluidigm, C1, BioMark, Luminex, ELISA, multiplex, immunoassay, qPCR, gene expression, RNA-seq, ATAC-seq, REAP-seq, miRNA expression, single cell, DNA-seq, sequencing, SNP genotyping, CNV, high throughput, protein analysis

  • Genetics & Genomics
  • Immunology/Antibody Production
  • Other -omics & Analytical
Carlton Anderson
canderson@med.unc.edu
(919) 260-3461
University of North Carolina at Chapel Hill
Kannapolis
More information/services:

Calorimetry, Cytoflex, Metabolic Cages, MRI, O2k, Oroboros, Phenotyping, Running Wheel, Seahorse, Treadmill

Stephen D. Hursting Ph.D. MPH
hursting@email.unc.edu
(919) 966-7346
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The UNC Animal Models Core provides custom genetically modified mice, rats and related services. Services are open to both UNC and non-UNC clients. Available services include model design, custom nuclease design (CRISPR/Cas), vector construction, gene targeting, ES cell screening, ES cell microinjection, transgene or nuclease pronuclear injection and model characterization.
More information/services:

Animal model design, CRISPR, knockout, knock-in & transgenic animals, ES cell gene targeting, blastocyst microinjection, pronuclear microinjection, targeting vector & transgene construction, ES cell derivation, model breeding

  • Genetics & Genomics
  • Model Systems
Dale Cowley, Ph.D.
dale_cowley@med.unc.edu
(919) 843-9125
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The UNC Biomarker Mass Spectrometry Core Facility provides expertise for qualitative and quantitative analysis of small molecular weight biomarkers including nucleic acids, peptides, and metabolites. In addition to LC/MS/MS analyses, we offer HPLC with UV detection and trace elemental analysis by ICP-MS. Areas of focus for the facility have included DNA and protein adducts as markers of chemical exposure, oxidative stress, and endogenous DNA damage, characterization of chemical reaction products, identification and quantitation of metabolites, multi-element analysis and arsenic speciation. The services and analyses performed within the facility enable investigators to study the molecular mechanisms of environmentally based diseases as well as the relationships between genetic and environmental factors. Research applications: Targeted quantitation of biomarkers of exposure and effect including DNA adducts, protein adducts, DNA-DNA and DNA-protein crosslinks, metabolites, and metals; Unbiased differential mass profiling; HPLC purification of reaction mixtures; Molecular weight and structural characterization of synthetic standards. Instrumentation: Sciex 6500 triple quad mass spec with Agilent 1290 Infinity II UHPLC; Thermo TSQ Quantum Ultra triple quad mass spec with Waters NanoAcquity UPLC; Thermo TSQ Quantum Ultra triple quad mass spec with Waters Acquity UPLC; Agilent 6520 Accurate-Mass Quadrupole Time-of-Flight mass spec with Agilent 1200 Rapid Resolution LC; Agilent 7500cx ICP-MS Inductively Coupled Plasma mass spec with Agilent 1260 Infinity Bioinert HPLC; Agilent 1200 HPLC for offline purification and fraction collection. Resources: Full service sample analyses as well as training for independent operation; Consultation for proposal submission and/or project feasibility; Method development; Data interpretation and generation of experimental sections and figures for publications. Fees are based on hourly usage of instrumentation and staff time, so costs correlate with the degree of effort required and the duration of analyses.
More information/services:

mass spectrometry, liquid chromatography, LC-MS. LC-MS/MS, ICP-MS

  • Other -omics & Analytical
Kun Lu
kunlu@unc.edu
(919) 966-7337
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The Center for Structural Biology is an integrated platform of expertise, education, and infrastructure for making structural biology available as a tool to the general researcher. Projects are carried out in a collaborative manner. CSB scientists work with and train students, post-docs and PIs, allowing the transfer of valuable know-how back into collaborating labs.
More information/services:

macromolecules at atomic resolution, small ligands (such as substrates, inhibitors, drugs), structural biology, novel therapies, structure-aided drug design

  • Bioprocessing
  • Biostatistics, Bioinformatics, & HPC
  • Cell/Tissue Culture & Flow Cytometry
  • Crystallography, X-ray Diffraction, NMR, & EPR
Ashutosh Tripathy
ashutosh_tripathy@med.unc.edu
(919) 962-4399
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The UNC Flow Cytometry Facility provides state-of-the-art flow cytometry and related services to the entire UNC-CH research community as well as to others in the Research Triangle Park area. A skilled staff provides cell sorting services, help with instrument setup, data analysis, and consultation for experiment design. Training is available to enable investigators and their staff to run the analytical cytometers themselves at reduced cost. A major part of our mission is to teach this technology to investigators, students, and staff. Please do not hesitate to contact us if you have any questions about flow cytometry, if you want to know if you can use it in your research, how to design experiments, prepare samples, or how to analyze your data.
More information/services:

Flow Cytometry analysis, Cell Sorting, BSL-2 containment, Cell Cycle, Cell Division, Protein expression, Microparticle analysis, Cell phenotyping with fluores. antibodies, viability, Signaling, Cytokine expression, Mass Cytometry

  • Cell/Tissue Culture & Flow Cytometry
Nancy C. Fisher, Ph.D.
Nancy_Fisher@med.unc.edu
(919) 966-7812