Shared Research Facilities and Equipment

Many facilities across North Carolina support life science research.

The listing covers core laboratory facilities at university and nonprofit research institutions that are open to researchers or collaborators outside of their home institutions.

Representatives of the core facilities listed below have voluntarily submitted their information. Not all institutions list available core lab facilities, but many are in the process of organizing and compiling these resources. As this information becomes available, we'll add those links.

NCBiotech has funded equipment in many core facilities in the state.

The Center's ongoing role is to provide this information portal.
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Region
Category
Facility Institution
Triangle
Chapel Hill

The CGIBD’s Advanced Analytics (AA) Core provides high-quality, quantitative solutions for studying proteins and nucleic acids at the bulk or single-cell level. The Core offers a wide variety of services, including: single cell genomics (10x Genomics and Fluidigm C1), single cell protein detection (Protein Simple Milo), high-throughput PCR/qPCR (Fluidigm BioMark HD), immunoassays (ELISA/EIA/multiplex), cell sorting (FACS), and Illumina sequencing (NextSeq 500).

More information/services:

10x Genomics, Fluidigm, C1, BioMark, Luminex, ELISA, multiplex, immunoassay, qPCR, gene expression, RNA-seq, ATAC-seq, REAP-seq, miRNA expression, single cell, DNA-seq, sequencing, SNP genotyping, CNV, high throughput, protein analysis

  • Genetics & Genomics
  • Immunology/Antibody Production
  • Other -omics & Analytical
Carlton Anderson
canderson@med.unc.edu
(919) 260-3461
University of North Carolina at Chapel Hill
Triangle
Chapel Hill

The UNC Animal Models Core provides custom genetically modified mice, rats and related services. Services are open to both UNC and non-UNC clients. Available services include model design, custom nuclease design (CRISPR/Cas), vector construction, gene targeting, ES cell screening, ES cell microinjection, transgene or nuclease pronuclear injection and model characterization.

More information/services:

Animal model design, CRISPR, knockout, knock-in & transgenic animals, ES cell gene targeting, blastocyst microinjection, pronuclear microinjection, targeting vector & transgene construction, ES cell derivation, model breeding

  • Genetics & Genomics
  • Model Systems
Dale Cowley, Ph.D.
dale_cowley@med.unc.edu
(919) 843-9125
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The UNC Biomarker Mass Spectrometry Core Facility provides expertise for qualitative and quantitative analysis of small molecular weight biomarkers including nucleic acids, peptides, and metabolites. In addition to LC/MS/MS analyses, we offer HPLC with UV detection and trace elemental analysis by ICP-MS. Areas of focus for the facility have included DNA and protein adducts as markers of chemical exposure, oxidative stress, and endogenous DNA damage, characterization of chemical reaction products, identification and quantitation of metabolites, multi-element analysis and arsenic speciation. The services and analyses performed within the facility enable investigators to study the molecular mechanisms of environmentally based diseases as well as the relationships between genetic and environmental factors. Research applications: Targeted quantitation of biomarkers of exposure and effect including DNA adducts, protein adducts, DNA-DNA and DNA-protein crosslinks, metabolites, and metals; Unbiased differential mass profiling; HPLC purification of reaction mixtures; Molecular weight and structural characterization of synthetic standards. Instrumentation: Sciex 6500 triple quad mass spec with Agilent 1290 Infinity II UHPLC; Thermo TSQ Quantum Ultra triple quad mass spec with Waters NanoAcquity UPLC; Thermo TSQ Quantum Ultra triple quad mass spec with Waters Acquity UPLC; Agilent 6520 Accurate-Mass Quadrupole Time-of-Flight mass spec with Agilent 1200 Rapid Resolution LC; Agilent 7500cx ICP-MS Inductively Coupled Plasma mass spec with Agilent 1260 Infinity Bioinert HPLC; Agilent 1200 HPLC for offline purification and fraction collection. Resources: Full service sample analyses as well as training for independent operation; Consultation for proposal submission and/or project feasibility; Method development; Data interpretation and generation of experimental sections and figures for publications. Fees are based on hourly usage of instrumentation and staff time, so costs correlate with the degree of effort required and the duration of analyses.
More information/services:

mass spectrometry, liquid chromatography, LC-MS. LC-MS/MS, ICP-MS

  • Other -omics & Analytical
Kun Lu
kunlu@unc.edu
(919) 966-7337
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The Center for Structural Biology is an integrated platform of expertise, education, and infrastructure for making structural biology available as a tool to the general researcher. Projects are carried out in a collaborative manner. CSB scientists work with and train students, post-docs and PIs, allowing the transfer of valuable know-how back into collaborating labs.
More information/services:

macromolecules at atomic resolution, small ligands (such as substrates, inhibitors, drugs), structural biology, novel therapies, structure-aided drug design

  • Bioprocessing
  • Biostatistics, Bioinformatics, & HPC
  • Cell/Tissue Culture & Flow Cytometry
  • Crystallography, X-ray Diffraction, NMR, & EPR
Ashutosh Tripathy
ashutosh_tripathy@med.unc.edu
(919) 962-4399
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The UNC Flow Cytometry Facility provides state-of-the-art flow cytometry and related services to the entire UNC-CH research community as well as to others in the Research Triangle Park area. A skilled staff provides cell sorting services, help with instrument setup, data analysis, and consultation for experiment design. Training is available to enable investigators and their staff to run the analytical cytometers themselves at reduced cost. A major part of our mission is to teach this technology to investigators, students, and staff. Please do not hesitate to contact us if you have any questions about flow cytometry, if you want to know if you can use it in your research, how to design experiments, prepare samples, or how to analyze your data.
More information/services:

Flow Cytometry analysis, Cell Sorting, BSL-2 containment, Cell Cycle, Cell Division, Protein expression, Microparticle analysis, Cell phenotyping with fluores. antibodies, viability, Signaling, Cytokine expression, Mass Cytometry

  • Cell/Tissue Culture & Flow Cytometry
Nancy C. Fisher, Ph.D.
Nancy_Fisher@med.unc.edu
(919) 966-7812
University of North Carolina at Chapel Hill
Triangle
Chapel Hill

The mission of the UNC Microbiome Core is to provide the research community with the facilities and expertise to characterize complex microbial communities and microbial interactions. The Core has state of the art instrumentation and extensively trained personnel that provide support from experimental design to data analysis. In addition to the services noted, the lab offers human bacterial isolates for mechanistic and interventional studies and microbiome metabolomics services.

More information/services:

Microbiome analysis including Illumina and Ion System library preparation, barcoding, and sequencing, and data analysis for amplicon, metagenomics shotgun and RNA sequencing. Standard, digital and high-throughput quantitative (q)-PCR.

  • Biorepository
  • Diagnostic Microbiology
M. Andrea Azcarate-Peril, PhD
azcarate@med.unc.edu
(919) 966-9838
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
NCore implements the mission of accelerating translation of new nanomedicines into clinic by providing comprehensive physical-chemical characterization of nanoscale entities. We offers researchers an opportunity for in-depth characterization of nanomaterials and carrier-mediated agents including: size, polydispersity, size distribution, count number of particles, chemical composition, isotope analysis, molar mass (Mw), purity, charge heterogeneity, and glycan analysis, PK and biodistribution studies, drug loading and drug release studies, exosomes characterization, etc.
More information/services:

Capillary Electrophoresis, DLS, FTIR, GPC, HPLC, ICP-MS, Nanoparticle Tracking Analysis, Plate reader, TGA, UV-Vis, Western Blotting.

  • Nanotechnology
  • Pharmaceutical & Drug Discovery
  • Other -omics & Analytical
Olesia Gololobova
ncore@unc.edu
(919) 962-1010
University of North Carolina at Chapel Hill
Triangle
Chapel Hill

The Protein Expression and Purification (PEP) core (part of the UNC Center for Structural Biology) specializes in the production of pure, functional proteins for structural, biophysical, and biochemical studies.

More information/services:

Expression Services, Protein Purification, Training and Consultation

  • Bioprocessing
  • Biostatistics, Bioinformatics, & HPC
  • Cell/Tissue Culture & Flow Cytometry
  • Crystallography, X-ray Diffraction, NMR, & EPR
Nathan Nicely
nathan.nicely@unc.edu
(919) 843-7174
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The Proteomics Core facility provides services for the analysis of proteins from tissues, cells or other biological samples. We are available to the UNC community, as well as external customers worldwide. We're committed to educating students and researchers in the field of proteomics and will work with you from initial experimental design through publication. We offer an array of sample preparation and instrumentation services, as well as method development and in-depth consultation to help researchers optimize their experimental design. The facility is equipped with three state-of-the-art systems: a Sciex 5800 MALDI-TOF/TOF, a Thermo Easy nLC 1000- QExactive HF, and a Waters nanoAcquity-Thermo LTQ-Orbitrap Velos. We offer several services including: protein identification, protein characterization, phosphoproteomics, large-scale proteomic profiling, and protein-protein interaction analyses.
More information/services:

mass spectrometry; LC/MS/MS; MALDI-TOF/TOF; CE/MS: protein identification; quantitative proteomics; post-translational modification identification; phosphoproteomics; targeted analyses; high-resolution intact mass analysis

  • Other -omics & Analytical
Laura Herring
laura_herring@med.unc.edu
(919) 966-4681
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
We provide consultations and collaborations on research studies requiring computational structural biology methods. The analyses available through the core (part of the UNC Center for Structural Biology) are not limited to the study of static structures, but also include molecular dynamics studies for analyzing the contribution of dynamic and collective motions to macromolecular functionality.
More information/services:

structure visualization, modeling and analysis, sequence analysis, Protein Data Bank (PDB) and Pymol Modeling

  • Bioprocessing
  • Biostatistics, Bioinformatics, & HPC
  • Cell/Tissue Culture & Flow Cytometry
  • Crystallography, X-ray Diffraction, NMR, & EPR
Brenda R. S. Temple
brenda_temple@med.unc.edu
(919) 843-9399