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Shared Research Facilities and Equipment

Many facilities across North Carolina support life science research.

The listing covers core laboratory facilities at university and nonprofit research institutions that are open to researchers or collaborators outside of their home institutions.

Representatives of the core facilities listed below have voluntarily submitted their information. Not all institutions list available core lab facilities, but many are in the process of organizing and compiling these resources. As this information becomes available, we'll add those links.

NCBiotech has funded equipment in many core facilities in the state.

The Center's ongoing role is to provide this information portal.
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Region
Category
Facility Institution
BRIC Small Animal Imaging Facility
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
The BRIC Small Animal Imaging facility provides imaging of small species, including mice, rats, etc., as well as in vitro specimens. On-site modalities include MRI, optical, CT, PET, SPECT and ultrasound. With expertise in study design, animal models, image acquisition and image analysis, the Small Animal Imaging facility helps investigators from grant application to publication. Services are available to investigators from all academic and industry labs.
More information/services:

imaging, small animal imaging, MRI, PET, microPET, SPECT, nuclear medicine, CT, microCT, ultrasound, US, optical, fluorescence, luminescence, autoradiography, DXA, DEXA, image analysis

  • Imaging & Microdissection
Hong Yuan, PhD
bricsai@unc.edu
(919) 843-3813
http://www.med.unc.edu/bric/small-animal-imaging
BRITE Drug Discovery Core
North Carolina Central University
Triangle
Durham

The drug discovery core facility is a state-of-the-art high throughput screening (HTS) facility with over 450,000 compound small molecule chemical libraries. It specializes in assay development, HTS, medicinal chemistry and chemo-informatics for drug discovery.

More information/services:

Assay development: cloning expression, protein production, High throughput screening: compound & database management, Medicinal chemistry: organic synthesis, SAR, parallel synthesis, nature product synthesis, Chemo-informatics: molecular modeling, QSAR

  • Pharmaceutical & Drug Discovery
kding@nccu.edu
(919) 530-7001
BRITE Imaging Core
North Carolina Central University
Triangle
Durham
This core facility offers high-resolution imaging of biological samples, including fluorescence microscopy, confocal high content imaging, and Widefield. It also features live cell imaging in high throughput format and calcium influx-efflux measurement using FLIPER.
  • Imaging & Microdissection
kding@nccu.edu
http://brite.nccu.edu/facility
BRITE Protein Expression and Purification Core
North Carolina Central University
Triangle
Durham
This core facility offers large-scale expression and purification services for biopharmaceutical research and performs investigations of protein stability/aggregation using several advanced methods.
More information/services:

30-liter bioreactor, E. coli, bacular virus, and mammalian cell expression systems, differential scanning calorimetry, self-interaction chromatography, dynamic light scattering, circular dichroism

  • Pharmaceutical & Drug Discovery
  • Other -omics & Analytical
kding@nccu.edu
http://brite.nccu.edu/facility
BRITE Technology Core
North Carolina Central University
Triangle
Durham
This facility features atomic force microscopy and biosensor development. It also offers laser scanning confocal microscope, 500 MHz NMR, flow cytometry, TOF-MS, and HTS capillary electophoresis.
  • Cell/Tissue Culture & Flow Cytometry
  • Imaging & Microdissection
  • Other -omics & Analytical
kding@nccu.edu
(919) 530-6884
BSOM Cellular Analysis/Imaging Core
East Carolina University
East
Greenville
This is a user-operated facility housing the following instrumentation to meet specialized microscopy, flow cytometer and protein quantification applications: -Zeiss PALM Laser Capture Microdissection scope -Zeiss LSM 700 Confocal with on stage incubation system -Becton Dickinson LSR II analytical flow cytometer (4laser, 14 channel detection)'- Protein Simple WES- an automated capillary/western assay system
More information/services:

Imaging, microdissection, flow cytometry, protein analysis

  • Cell/Tissue Culture & Flow Cytometry
  • Imaging & Microdissection
Cindy Kukoly
kukolyc@ecu.edu
(252) 744-2962
http://www.ecu.edu/cs-dhs/bsomresearchgradstudies/coreimagingcenter/
CALS Center for Electron Microscopy
North Carolina State University
Triangle
Raleigh
The CALS Center for Electron Microscopy provides scanning and transmission electron microscopy services including associated tissue preparation for the biological sciences. Digital imaging services are also available.
More information/services:

Transmission electron microscopy, Scanning electron microscopy, TEM, SEM, Ultramicrotomy, Critical point drying, Sputter coating, Biological samples, Digital Imaging

  • Imaging & Microdissection
Valerie Knowlton Lapham
valerie_knowlton@ncsu.edu
(919) 515-2664
https://harvest.cals.ncsu.edu/structural-biochemistry-resource/electron-microsc…
Campbell University Pharmaceutical Education and Research Center
Campbell University
Triangle
Buies Creek
The Pharmaceutical Education & Research Center (PERC) at Campbell University offers a wide variety of analytical, formulation, R&D, and training services to pharmaceutical and biotechnology industries, compounding pharmacies, and academic institutions.
More information/services:

Pre-Clinical Trial Materials, Analytical Testing, Formulation Development, Stability Testing, Analytical Method Development

  • Crystallography, X-ray Diffraction, NMR, & EPR
  • Pharmaceutical & Drug Discovery
  • Other -omics & Analytical
Mali R. Gupta, Ph.D.
guptam@campbell.edu
(910) 893-1694
http://www.campbell.edu/PERC
Campbell University Pharmaceutical Education and Research Center (PERC)
Campbell University
Triangle
Buies Creek
The Pharmaceutical Education & Research Center (PERC) at Campbell University offers a wide variety of analytical, formulation, R&D, and training services to pharmaceutical and biotechnology industries, compounding pharmacies, and academic institutions.
More information/services:

Pre-Clinical Trial Materials, Analytical Testing, Formulation Development, Stability Testing, Analytical Method Development

  • Crystallography, X-ray Diffraction, NMR, & EPR
  • Pharmaceutical & Drug Discovery
  • Other -omics & Analytical
Mali R. Gupta, Ph.D.
guptam@campbell.edu
(910) 893-1694
http://www.campbell.edu/PERC
Cell Biology/Ultrastructure Core Research Facility
University of North Carolina at Chapel Hill
Triangle
Chapel Hill
This facility provides dedicated 3,000 sq. ft. designed for high resolution imaging and physiologic studies of airway epithelial cell structure/function.
More information/services:

Transmission electron microscopy, scanning electron microscopy, freeze-fracture, immunohistochemistry, high speed video analysis

  • Human Performance, Nutrition, & Physiology
  • Imaging & Microdissection