BTEC Seminar: Utilizing Oxygen Transfer Rate as a Core Parameter for Shaken Bioprocess Monitoring & Optimization

Shaken bioprocesses rely heavily on the oxygen transfer rate (OTR) as an indirect measure of the oxygen uptake rate (OUR) to infer a cultivation's metabolic activity. However, accurately capturing this parameter online has historically been challenging in a shaken vessel.

 This presentation reviews OTR as a critical bioprocess parameter — covering its fundamental definition and how the Kuhner TOM system enables real-time tracking. Finally, we will explore practical application examples, demonstrating how utilizing OTR data directly optimizes shaken bioprocess workflows.

Speaker

Michael Keebler, Ph.D., Associate Director of Applied Technologies at Kuhner Shaker, Inc.

Michael manages several product lines for North America, including the Kuhner TOM, the Kuhner Feeding Technology, and the Kuhner OSB series. Mike also manages Sales in the Bay Area and is the primary Application Scientist for Kuhner Shaker, Inc., specializing in hydrodynamics and the process parameters of shaken cultivation.