Optimization of a Plasmid-DNA-Hyperproducing E. coli Strain Using Inducible Directed Evolution
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Organization
North Carolina State University
Award Date
Award Amount
110,000
Program Name
Translational Research Grant
Program Category
Research and Equipment Support
Principal Investigator
Nathan Crook
Fiscal Year
2022
Region
Research Triangle
Project Description:
Plasmid DNA is a critical component for the production of gene therapies and mRNA vaccines; however, plasmid DNA is very expensive to manufacture. Researchers at NCSU will test a novel process that has the potential to greatly reduce the cost of plasmid DNA production.