Differential Inhibition of Human P450 27A1 for Breast Cancer Treatment
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Organization
Appalachian State University
Award Date
Award Amount
20,000
Program Name
Flash Grant
Program Category
Research and Equipment Support
Principal Investigator
Michael Reddish
Fiscal Year
2021
Region
Western
Project Description:
An emerging strategy for the treatment of breast cancer is the reduction of 27-hydroxyholesterol levels by inhibiting the enzyme cytochrome P450 27A1. Scientists at Appalachian State University will test two approved drugs, procarbazine and dasatinib, to see if they inhibit the cholesterol reactions of P450 27A1 while maintaining its role in vitamin D3 metabolism.