Improving the Oral Bioavailability and In vivo Efficacy of the TAK 1 Inhibitor, Takinib.
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Organization
Duke University Medical Center
Award Date
Award Amount
100,000
Program Name
Biotechnology Innovation Grant
Program Category
Research and Equipment Support
Principal Investigator
Timothy Haystead
Fiscal Year
2019
Region
Research Triangle
Project Description:
For many rheumatoid arthritis (RA) patients, anti-TNF drugs have transformed their lives. Anti-NF drugs have been shown to slow or stop joint damage caused by RA. However 40% of patients do not respond to these types of drugs and many responsive patients develop resistance over time. Takinib is a novel drug-like molecule specifically targeting the anti-inflammatory pathways of TNF. The goal of this project is to develop this molecule as an oral medication and develop it as an alternative to current therapies.