Biomaterial-Assisted In Situ Generation of CAR-T Cells
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Organization
North Carolina State University
Award Date
Award Amount
24,000
Program Name
Flash Grant
Program Category
Research and Equipment Support
Principal Investigator
Yevgeny Brudno
Fiscal Year
2019
Region
Research Triangle
Project Description:
CAR T-therapy enlists a patient's own immune system to fight cancer. Typically, a patient’s immune cells are collected and isolated in a laboratory, which requires a lot of labor and costly cell manipulation, limiting its widespread use. The proposed research will test a radical alternative, where an implanted scaffold recruits, reprograms, and releases CAR-T cells inside of patients - completely eliminating cell manipulation outside of the patient’s body.