Adenovirus E4orf6 Variants to Enhance the Production of AAV Viral Vectors
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Organization
Wake Forest University Health Sciences
Award Date
Award Amount
110,000
Program Name
Translational Research Grant
Program Category
Research and Equipment Support
Principal Investigator
David Ornelles
Fiscal Year
2020
Region
Piedmont
Project Description:
Children are being turned away from life-changing clinical trials in gene therapy because of the inability to produce sufficient small adenovirus proteins that are required to deliver the genes to the correct cells. However, the process of making the proteins in cells is toxic to those cells, which limits the amount of protein that can be produced. This project will develop non-toxic variants that can be used in current manufacturing process to increase production for gene therapy.