Non-immunogenic PEG-like Conjugates of Biologics
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Organization
Duke University
Award Date
Award Amount
100,000
Program Name
Biotechnology Innovation Grant
Program Category
Research and Equipment Support
Principal Investigator
Ashutosh Chilkoti
Fiscal Year
2016
Region
Research Triangle
Project Description:
Attaching peptide and protein drugs to poly(ethylene glycol) (PEG) is a clinically proven method to increase their effectiveness. However PEG induces an undesirable antibody response in some patients. This research will solve this problem by design of a new PEG-like polymer that retains its efficacy but abolishes its antibody response.