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Small Business Research Loan (SRL)

Maximum Award: 

Program Description

The SRL Program funds research to advance development of commercially viable technologies/products. Through the SRL program, loans of up to $250,000 are available for life science companies in North Carolina. This program supports companies in reaching specific and meaningful research milestones that would position them to obtain additional funding from private and public sources.


In order for a candidate life science company to be eligible to apply for the SRL, it must:

  • Have significant operating presence in North Carolina. To establish a significant presence, the company must (i) maintain its head office (where its books and records are kept, taxes are paid, and senior management is located) in North Carolina as reported to the Secretary of State and/or (ii) conduct significant research, product development, or manufacturing activity in North Carolina.
  • Be engaged in life science research, development or manufacturing to develop a product or technology with commercial potential.
  • Have achieved a robust technical and commercially promising proof-of-principle of its technology for the intended product or application.
  • Have a committed, dedicated management team and a solid business plan.
  • Have a valid license(s) to the relevant core intellectual property expected to be necessary for the company to commercialize its product or technology.
  • Have completed all project(s) funded by any previously-awarded NCBiotech loan(s).

NCBiotech determines compliance with these requirements in its sole discretion on a case-by-case basis.

Application Process

Companies interested in applying for an SRL should contact NCBiotech's SRL program director listed in the Contact section below to discuss the company, its proposed project, and the application procedures. After this discussion, company representatives may be invited to the Biotechnology Center to make an initial presentation.

Pre-Application: Once the applicant’s eligibility and general fit for the program have been established, the company may be invited to submit a pre-application describing the company’s management, technology, proposed project, and budget.

Full Application: Upon satisfactory review of the pre-application, the company may be invited to submit a full application. This application will include the company’s complete business plan, project proposal, financial statements and other supporting documentation.

Review and Approval: The Business and Technology Development team will thoroughly review the company’s application and solicit independent, third-party reviewers to help evaluate the technical and commercial merits of the proposal. Competitive applications will be presented to the NCBiotech’s Equity Investment Committee (EIC) for final review and approval.

Application Deadlines:

Pre-Application must be
submitted no later than:
And Full Application
must be submitted by:
For potential review
by EIC in:
October 31, 2014 December 5, 2014 March 2015
January 30, 2015 March 6, 2015 June 2015
May 8, 2015 June 12, 2015 September 2015
July 31, 2015 September 4, 2015 December 2015

Loan Terms

The SRL is a senior, unsecured loan with favorable terms including:

  • Three-year loan with balloon payment at maturity for principal and accrued interest.
  • Interest rate equal to the current prime rate plus 3%.
  • Warrant coverage for a portion of the loan principal amount.

Loan Distribution

Successful applicants will receive the loan funds according to the following schedule:

  • 50% of the loan amount at closing.
  • An additional 40% upon receipt and approval of a mid-term project report.
  • The final 10% upon receipt and approval of a final project report.

Mid-term and final reports include a detailed update of progress against proposed milestones (including supporting data) and actual spending versus budget. The Biotechnology Center will actively monitor the company’s progress until the SRL is repaid in full. Periodic progress reports and occasional site visits will be required.

 FY 2012
 SRL Awards
 FY 2013
 SRL Awards
 FY 2014
 SRL Awards
 FY 2015
SRL Awards

Applied Catheter 


CivaTech Oncology 


G-1 Therapeutics 


Trana Discovery 


Zoion Pharma 


Aerial Biopharma 


CertiRx Corp. 


Galaxy Diagnostics




Novocor Medical Systems 


Oncotide Pharmaceuticals 








Agile EndoSurgery 


Camras Vision 




Contego Medical 




Lucerno Dynamics 






Panacea BioMatx 




SciKon Innovation 


T3D Therapeutics 


Novocor Medical Systems 


Dignify Therapeutics 








FLAG Therapeutics 


Eppin Pharma 


Kaio Therapy 


NIRvana Sciences 


Akros Medical 



Contact Vivian Doelling at with questions regarding this program or to schedule a preliminary meeting.