Venture Capital and Angel Investor Groups

Alexandria Real Estate Venture

Alexandria’s strategic venture capital platform. Since its inception in 1996, they have invested in disruptive life sciences, agrifood tech, climate innovation, and technology companies advancing transformative new modalities and platforms to improve human health. They invest in seed-, early-, and growth-stage companies, accelerating discoveries across a range of emerging technologies and novel modalities.

Cape Fear Biocapital 

Cape Fear is a Durham-based investment firm that makes seed investments into early-stage biotechnology companies. Their focus is on platform and individual therapeutics opportunities. 

Coddle Creek Capital 

Coddle Creek Capital is an early-stage investor in the life sciences sector, focusing on the sub-sectors of genomics, nutrition, immunology, oncology, microbiome, and neurology. 

Cone Health Ventures (CHV)

Cone Health Ventures partners with digital health/healthtech and med tech companies to shorten the development cycle and accelerate market adoption.  

Echo Health Ventures (Echo)

Echo focuses on hands-on, purpose-driven strategic venture capital and growth equity investing to catalyze healthcare transformations that improve outcomes, reduce costs, and enhance quality. They primarily invest in telemedicine, digital health, and healthcare technology solutions.  

Eshelman Ventures

Eshelman Ventures is a Wilmington-based fund that invests in various ways, including as an angel investor or alongside venture capital or private equity funds. They concentrate on healthcare, including transformative therapeutics. 

Excelerate Health Ventures (EHV)

Excelerate is a digital health-focused fund for early-stage companies.  

Gaston Capital

Gaston Capital is a growth equity investor that participates on a standalone basis or as a co-investor. They target cash-flow-positive companies across various sectors, including healthcare (therapeutics and medical technology). 

Hatteras Venture Partners (HVP)

Hatteras Venture Partners is a venture capital firm formed to invest primarily in early-stage companies with a focus on biopharmaceuticals, medical devices, diagnostics, healthcare IT, and related opportunities in human medicine. 

IDEA Fund Partners

IDEA Fund Partners is a seed and early-stage venture capital firm focused on investing in and working alongside innovative technology companies in the Southeast and Mid-Atlantic regions. They are a generalist technology investor but have historically invested in B2B software and services and some healthtech.  

Jupiter Bioventures

Jupiter Bioventures is a biotechnology venture formation group that builds therapeutics companies. Jupiter scaffolds a promising project with a team and small amounts of seed capital to experimentally validate the core idea. The most promising projects receive additional funding to become freestanding companies. 

KdT Ventures (KdT)

KdT is an NC-based early-stage investor focused on creative technology platforms across diverse tech sectors including therapeutics, biomanufacturing, healthtech, agriculture, chemistry, materials science, and robotics. 

NovaQuest Capital Management

NovaQuest makes product-based investments in late-stage clinical and commercial biopharmaceutical programs. They also invest in animal health.

​​​​​​Oval Park Capital

Based in Raleigh, NC, Oval Park is an early-stage venture capital firm that primarily invests in the Southeastern US. Their investments target unregulated deep technology, B2B software, and biotechnology across diverse verticals including robotics, automation, artificial intelligence, computing, and microfluidics. They do not invest in FDA-regulated companies.  

Pappas Venture  

Pappas Ventures invests exclusively in life sciences companies, with a focus on undercapitalized markets including its home territory of Research Triangle Park. Their investments span therapeutics, medtech (devices and diagnostics), and drug delivery solutions.  

Pisgah Fund

The Pisgah Fund invests in healthcare-related companies in Western North Carolina’s 18-county region (or companies locating operations in this region). Hatteras Venture Partners manages the Fund. 

Rex Health Ventures (RHV)

Rex Health Ventures is a strategic investor that operates as the early-stage investment fund for all of UNC Health System. They invest in and partner with companies that are advancing the future of human health.  

River Cities Capital Funds (RCC)

RC Capital is a growth equity firm with offices in Cincinnati, Ohio and in Raleigh, North Carolina. They are focused on building high-potential healthcare companies and focus their investments on medical devices, healthcare services, and healthcare IT.  

Tidewater Equity Partners

Tidewater Equity Partners is a Wilmington-based investment firm that uses a variety of vehicles (debt, private equity, venture capital). They make investments in healthcare and biotech, focusing on revenue-generating or late-stage opportunities.

VentureSouth Asheville

VentureSouth Asheville is a member-based angel network and local chapter of VentureSouth. They invest in early-stage companies in Asheville and across the Southeast.  

Carolina Angel Network (CAN)

The Carolina Angel Network provides an angel investing platform and co-investment fund that leverages the UNC alumni network. Portfolio companies must have a UNC affiliation and be headquartered in the United States. They will invest in medical devices and biotechnology but not drug development. 

Charlotte Angel Fund (CAF)

The Charlotte Angel Fund invests in early-stage companies throughout North Carolina and contiguous states. Its members are residents of or have interests in the Charlotte area. They invest in a variety of areas, including healthcare and food science. 

Duke Capital Partners

Duke Capital Partners supports the Duke entrepreneurial community with an angel investing platform and co-investment fund that leverages the Duke alumni network. Companies must have a Duke affiliation and be located in the United States. They invest across enterprise, consumer, and life sciences sectors. 

RTP Capital Associates

RTP Capital is an angel network focused on seed and early-stage investing in the Research Triangle Park region of North Carolina. They have broad investment interests but focus on technology-centric businesses that are near revenue and 3-5 years from exit. 

SeaAhead Blue Angels 

The Blue Angels are accredited impact investors who work together to make seed and Series A deals in the bluetech sector. Their interests include ocean intelligence, coastal resilience, overfishing reduction, aquaculture technologies, plastic alternatives, and innovations that apply to offshore renewable energy. 

Sustainable Food Ventures 

Sustainable Food Ventures uses an angel platform to make investments in early-stage founders building food companies that are cell-based, plant-based, or recombinant. 

RTP Angel Fund 

RTP Angel Fund consists of a diverse group of members that invest in early-stage ventures in North Carolina, primarily targeting the Research Triangle Park region. Their investment focus is broad but includes medtech, diagnostics, and healthtech. 

VentureSouth

VentureSouth invests in early stage companies based in the Southeast. Their investments focus on companies that are ready to launch or scale a market-ready product or service. They invest across diverse sectors including biotech, healthcare, and agriculture. 

Wolfpack Investor Network 

The Wolfpack Investor Network provides an angel investing platform and co-investment fund that leverages the NC State alumni network. Portfolio companies must have an NC State affiliation and be headquartered in the United States. They invest across diverse categories including diagnostics, medtech, therapeutics, food science, and healthtech.