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Using RNA Interference to Identify New Drug Targets in the Human Pathogenic Fungus, Cryptococcus neoformans

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Award date: 
Jun 14, 2012
Award amount: 
Organization name: 
Western Carolina University
Principal Investigator: 
Bose, Indrani
Grant program category: 
Research and Equipment Support
Grant program name: 
Biotechnology Research Grant

Cryptococcus neoformans, a fungus that infects immunocompromised patients, may cause fatal meningoencephalitis if left untreated. Current antifungals have little efficacy against this organism. We will construct and screen an RNA interference library to identify novel genes required for melanization (a virulence factor) that could serve as new drug targets.

Fiscal year: