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Use of Autologous Macrophages for Sustained Delivery of GDNF as Treatment of Parkinson's Disease

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Award date: 
Jun 30, 2015
Award amount: 
Organization name: 
UNC - Chapel Hill
Principal Investigator: 
Doherty, Jason
Grant program category: 
Research and Equipment Support
Grant program name: 
Technology Enhancement Grant
Research Triangle

This proposal will develop the cell-mediated drug delivery system, where autologous macrophage are utilized for the transport of neuronal growth factors to the brain. We will extend the studies to the MitoPark mouse -- a validated model of Parkinson's disease to assess product's therapeutic potential and evaluate potential neuroprotective effects.

Fiscal year: