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Towards Rational Engineering of Transposon-based Genetic Tools

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Award date: 
Jun 14, 2012
Award amount: 
Organization name: 
UNC - Charlotte
Principal Investigator: 
Nesmelova, Irina V.
Grant program category: 
Research and Equipment Support
Grant program name: 
Biotechnology Research Grant
Greater Charlotte

The goal is to use biotechnology for engineering novel hyperactive Sleeping Beauty (SB) transposons with better controlled, site-specific DNA-binding for gene therapy and other genetic applications. The first structural study of SB transposase using nuclear magnetic resonance spectroscopy will provide structural information needed for transposon engineering.

Fiscal year: