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Precision Health Resources

The mission of the Precision Health Initiative is to enable a new era of medicine through research, technology, and policies that empower patients, researchers, and providers to work together toward development of individualized care.


IGNITE Toolkit - Supporting Practice through Application, Resources, and Knowledge

View the SPARK toolbox for more information and tools for clinicians, researchers, educators and patients - all to support the practice of implementing genomics in practice.​

GeneTests is a medical genetics information resource developed for physicians, genetic counselors, other healthcare providers and researchers to improve and simplify searches for genetic tests, clinics and related information.

Tier 1 Genomic Applications Toolkit for Public Health Departments was developed so that state public health departments, health care providers and payers, and anyone interested can quickly learn about Tier 1 applications, partnership building, and other action steps that can lead to saving lives. While this format seeks efficiency through brevity, many links to more detailed resources are provided through hyperlinked text. Because the toolkit is designed as a “living document” the information will be updated as the rapidly evolving field of public health genomics changes – including the addition of more Tier 1 applications when new evidence based recommendations or subsequent action steps are available. 

Precision Health and Public Health

  • Guidelines: This database contains updated public health genomics guidelines, policies and recommendations on genomic research and practice, as provided by professional organizations, federal advisory groups, expert panels and policy groups.

  • Evidence-Generation: Using horizon scanning (a systematic research method to find and follow novel technologies appearing in the literature) the Office of Public Health Genomics identifies and tracks the progress of genomic tests as they move from research into clinical and public health practice. While all three tiers are important, Tier 1 represents the greatest progress, requiring: a) FDA label requires use of test to inform choice or dose of a drug; b) CMS covers testing; and c) Clinical practice guidelines based on systematic review supports testing.

  • My Family Health Portrait: An internet-based tool developed by the U.S. Surgeon General and managed by the National Human Genome Research Institute that makes it easy for you to record your family health history. It assembles your information and makes a "pedigree" family tree that you can download.

  • Education to Engage Patients - Health DataA patient-centered approach to demystify health data. 

    A knowledge gap exists between what people understand about the R&D system and what the system is asking them to do. The average person feels that the health-care system collects an immense amount of information from them. So they wonder, what more does my care team need me to do? What are they doing with the data they already have?

    To help bridge the gap, the ‘health data basics’ tool is being developed to help people understand what makes up their health data, how they are collected and shared, and who uses them, so they have the basic knowledge needed to use these data when making decisions about their health.

National resources 

  • Precision Medicine Initiative: Health care tailored to you. The White House unveils the Precision Medicine Initiative - a bold new research effort to revolutionize how we improve health and treat disease.

  • All of Us Research Program: The All of Us Research Program, formerly known as the Precision Medicine Initiative Cohort Program, will be a participant-engaged, data-driven enterprise supporting research at the intersection of lifestyle, environment, and genetics to produce new knowledge with the goal of developing more effective ways to prolong health and treat disease.

  • The Personalized Medicine Coalition: The Personalized Medicine Coalition (PMC), representing innovators, scientists, patients, providers and payers promotes the understanding and adoption of personalized medicine concepts, services and products to benefit patients and the health system. The Coalition’s priority areas are education and advocacy.

  • National Academies of Medicine – Roundtable on Genomics and Precision Health and Action Collaboratives: The Roundtable on Genomics and Precision Health brings together leaders from government, academia, industry, foundations, associations, patient communities, and other stakeholder groups to meet and discuss global issues surrounding the translation of genomics and genetics research findings into medicine, public health, education, and policy. The Genomics and Population Health Action Collaboratives convene key stakeholders with an interest in and commitment to integrating genomics in existing population health programs for health improvement.

  • The Office of Public Health Genomics: The Office of Public Health Genomics provides updated and credible information on how genomic information and family health history can improve health and influence policy and practice. We highlight news and information on the use of genomic tests and other applications, including family health history, in clinical and public health practice and programs, along with relevant data, policy, and legislation.

  • Tier 1 Toolkit for Public Health Departments: Several Tier 1 Genomics Applications are important to the public health community.  In this toolkit, public health departments will find applications for assessing risk for citizens and their family members for Lynch Syndrome, Hereditary Breast and Ovarian Cancer (HBOC), and Familial Hypercholesterolemia (FH).

  • HuGE Navigator: An online catalog of published population studies of human gene-disease associations complied by the Centers for Disease Control and Prevention (CDC) Office of Public Health Genomics.

  • CDC Genomics and Public Health Weekly Update Newsletter: A free weekly online Genomics and Health Impact newsletter about the latest in genomics and public health. If you are interested in receiving this weekly update from the CDC, please subscribe.

State resources

  • RENCI South Big Data Hub: The South Big Data Regional Innovation Hub (South BD Hub), is one of four Big Data Regional Innovation Hubs established in 2015 by the  National Science Foundation (NSF). The BD Hub initiative aims to build innovative public-private partnerships that address regional challenges such as health care (including precision medicine), habitat planning, and coastal hazards through big data analysis.

  • RTI Precision Medicine: The RTI team leverages its collective expertise in genomics, proteomics, metabolomics, the microbiome, and biomarker discovery to better understand disease states and inform individualized approaches to treatment and prevention.

  • Duke’s Applied Genomics & Precision Medicine: The Duke Center for Applied Genomics & Precision Medicine was created to focus on developing interdisciplinary science and pragmatic implementation strategies and capabilities to enhance our ability to diagnose and predict patient outcomes across the continuum from health to disease.

  • UNC College of Medicine: The Department of Genetics and the Lineberger Comprehensive Cancer Center are actively engaged in precision medicine. The Department of Genetics focuses on providing basic and applied genetic/genomic research, education and training, while the Lineberger Center is leading an emerging scientific approach to cancer treatment that is building on advances in genetic sequencing.

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