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Non-immunogenic PEG-like Conjugates of Biologics

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Award date: 
Jun 7, 2016
Award amount: 
Organization name: 
Duke University
Principal Investigator: 
Chilkoti, Ashutosh
Grant program category: 
Research and Equipment Support
Grant program name: 
Biotechnology Innovation Grant
Research Triangle

Attaching peptide and protein drugs to poly(ethylene glycol) (PEG) is a clinically proven method to increase their effectiveness. However PEG induces an undesirable antibody response in some patients. This research will solve this problem by design of a new PEG-like polymer that retains its efficacy but abolishes its antibody response.

Fiscal year: