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Intramyocardial EphrinA1-Fc Reduces Myocardial Infarct Injury (Resubmission)

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Award date: 
Jun 14, 2012
Award amount: 
Organization name: 
East Carolina University
Principal Investigator: 
Virag, Jitka A.I.
Grant program category: 
Research and Equipment Support
Grant program name: 
Biotechnology Research Grant

The investigator will examine the mechanisms by which ephrin A1-Fc provides protection against injury to the heart muscle after blood flow is cut off to the organ and in the absence of reperfusion therapy. The cell signaling pathway intermediates through which ephrin A1-Fc acts to enhance cardiomyocyte survival are as yet unknown. Understanding these mechanisms will reveal the therapeutic potential of ephrinA1-Fc for cardiovascular diseases and stroke, as well as tissue engineering and regenerative applications.

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