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Intramyocardial EphrinA1-Fc Reduces Myocardial Infarct Injury (Resubmission)

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Award date: 
Jun 14, 2012
Award amount: 
Organization name: 
East Carolina University
Principal Investigator: 
Virag, Jitka A.I.
Grant program category: 
Research and Equipment Support
Grant program name: 
Biotechnology Research Grant

Intramyocardial administration of EphrinA1-Fc significantly reduces ischemic injury in nonreperfused murine myocardial infarction. The cell signaling pathway intermediates involved that enhance cardiomyocyte survival are as yet unknown. Understanding these mechanisms will reveal the therapeutic potential of ephrinA1-Fc for cardiovascular diseases and stroke, as well as tissue engineering and regenerative applications.

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