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Genetic Variation of Plasma Disposition Kinetics and Liver Gene Expression in the Pig and their Implications on Animal Welfare and Drug Efficacy (Resubmission)

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Award date: 
Oct 25, 2011
Award amount: 
Organization name: 
North Carolina State University
Principal Investigator: 
Ashwell, Melissa S.
Grant program category: 
Research and Equipment Support
Grant program name: 
Multidisciplinary Research Grant
Research Triangle

Current FDA drug withdrawal times in swine are based on information from relatively few animals and do not take into account differences among breeds. This approach may result in drug administration at too low or too high levels, increasing veterinary costs and possibly cultivating drug resistance. This project will examine drug withdrawal times in pig breeds to evaluate the role of genetic variation in drug metabolism.

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