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Development of Novel Peptides to Treat Diseases of Na+ Absorption (Resubmission)

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Award date: 
Jun 4, 2013
Award amount: 
$300,000
Organization name: 
UNC - Chapel Hill
Principal Investigator: 
Tarran, Robert
Grant program category: 
Research and Equipment Support
Grant program name: 
Multidisciplinary Research Grant
Region: 
Research Triangle

As a result of a gene defect, patients with cystic fibrosis have thick mucus in their airways that is hard to clear, leaving their lungs prone to mucus plugging and infections. The thick mucus results from an imbalance in salt and water transport in their lungs. Investigators propose to develop novel peptides that can inhibit excessive salt absorption in CF airways to improve CF mucus hydration and prevent infection.

Fiscal year: 
2013